Rockland/雄激素受体磷酸化S94抗体/600-401-W93/100µL
商品编号：
600-401-W93
品牌：
rockland-inc
市场价：
¥7100.00
美元价：
4260.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AndrogenReceptorPhosphoS94AntibodyProperties Description Anti-AndrogenReceptorpS94(RABBIT)Antibody-600-401-W93 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,Non-humanprimates Clonality Polyclonal Application ELISA:1:10,000 WesternBlot:1:1000 PhysicalState Liquid(sterilefiltered) ShippingCondition WetIce Format IgG Label Unconjugated Buffer 0.01MHEPES,0.15MSodiumChloride,pH7.5 Preservative None StABIlizer 50%(v/v)Glycerol GeneName AR RelevantLinks UniProtKB-P10275 GeneID-367 NCBI-NP_001011645 |
AndrogenReceptorPhosphoS94AntibodyDescription
Background
Theandrogenreceptor(AR)isaDNA-bindingtranscriptionfactorthatregulatesgenescriticalforthedevelopmentandmaintenanceofthemalesexualphenotype.Defectsinandrogenreceptorhavebeenshowntoplayaroleinprostatecancer,andinhibitionofARactivitythroughmodulationofsignaltransductionpathwaysmaydelayprostatecancerprogression.Multiplephosphorylationsiteshavebeenidentifiedontheandrogenreceptorthataffectcross-talkbetweengrowthfactorsignalingandandrogeninprostatedevelopmentandcancer.Oneofthesesites,atSer94,appearsconstitutivelyphosphorylatedandexhibitsnoresponsetotreatmentswithstimulatinghormone.ThesiteatSer94isuniqueamongtheARphosphorylationsitesinthatitdoesnotachieveamaximallevelofphosphorylationbetweentranslationandtheinitialroundofnuclearimport,havingastrongbiasforandrogen-independentphosphorylationinthecytoplasm.AndrogenReceptorpS94Antibodyisidealforresearchersinterestedincancerresearch.
Synonyms
Dihydrotestosteronereceptor,Nuclearreceptorsubfamily3groupCmember4
Immunogen
Anti-Phospho-Ser94AndrogenReceptorAntibodywasproducedinrabbitsbyrepeatedimmunizationswithasyntheticphospho-peptidecorrespondingtoaminoacidresiduessurroundingthephosphorlyatedSer94ofhumanARconjugatedtoKLH.
ImmunogenType
Peptide
PostTranslationalModification
Phosphorylation
StorageCondition
Storevialat-20°Cpriortoopeninginundilutedaliquots.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-Phospho-Ser94AndrogenReceptorAntibodyisstoredwith100µgpermlBSA.ThisantibodyisspecificforthepS94andissufficentfor10Westernblots.Expectabandatapproximately~110kDaonspeificlysatesortissues.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.
Purity/Specifity
Anti-Phospho-Ser94AndrogenReceptorAntibodywaspreparedfromrabbitserumbyaffinitypurificationviasequentialchromatographyonphospho-anddephosphopeptideaffinitycolumns.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍
美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。 另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。
