Rockland/5-脂氧合酶磷酸化S523抗体/600-401-D03/100µL
商品编号:
600-401-D03
品牌:
rockland-inc
市场价:
¥7100.00
美元价:
4260.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
5-LipoxygenasephosphoS523AntibodyPropertiesDescription Anti-5-LipoxygenasepS523(Rabbit)Antibody-600-401-D03 Host Rabbit TargetSpecies Human KnownCrossReactivity human,rat,mouse Clonality Polyclonal Application ELISA:1:10,000 WesternBlot:1:1000 PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.01MHEPES,0.15MSodiumChloride,pH7.5 StABIlizer 0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol GeneName ALOX5 RelevantLinks UniProtKB-P09917 GeneID-240 UniProtKB-P09917.2 |
5-LipoxygenasephosphoS523AntibodyDescription
Background
5-LipoxygenasepS523antibodyrecognizestheenzyme5-lipoxygenase(5-LO)whichplaysakeyroleinregulatingtheproductionofleukotrienes(LTs).OverproductionofLTscontributestoseveraldiseases,mostnotablychronicinflammatorydiseases,includingasthma,fibrosisandatherosclerosis.Recentworkhasdemonstratedthattheactivityof5-LOisregulatedbyPKAphosphorylationofserine-523in5-LO.Undernormalconditions,thisphosphorylationmaybeimportantinlimitinginflammation.AbnormalsignalingthroughcAMPandPKA,then,couldcontributetoavarietyofdiseases,includingthosecharacterizedbychronicinflammation.Thephospho-specificantibodytoSer523on5-LOisthuslikelytoprovideavaluabletoolforstudiesoftheroleof5-LOregulationindiseasessuchasasthma,fibrosisandatherosclerosis.Anti-5-LipoxygenasepS523antibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
Arachidonate5-lipoxygenase,5-LO
Immunogen
Anti-5-LipoxygenasepS523Antibodywasproducedbyrepeatedimmunizationswithsyntheticphospho-peptidecorrespondingtoaminoacidresiduessurroundingSer523.
ImmunogenType
Peptide
PostTranslationalModification
Phosphorylation
StorageCondition
Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-5-LipoxygenasepS523antibodyissuitableforuseinWesternBlottingandELISA.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately80kDacorrespondingtothe80kDa5-LOproteinsphosphorylatedatSer523.
Purity/Specifity
Anti-5-LipoxygenasepS523Antibodyisdirectedagainsthuman5-LipoxygenasephosphorylatedatS523.Theantibodyisaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.Reactivityisexpectedfromthefollowingspeciesbasedon100%sequencehomology:nonhumanprimates.Crossreactivitywith5-LipoxygenasepS523fromotherspecieshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍
美国Rockland是一家老牌抗体原产企业,其位于美国费城郊区的农场保有近20种实验动物,全部按美国农业部实验动物规范饲养和操作,是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产,国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品,以全面,价格合理为特色。今年,Rockland也加大了在一抗方面的投资力度,新生物分子的抗体数量每年都大幅增长,而这又是以其强大的重组蛋白表达能力为基础的。美国Rockland公司为生命科学领域提供丰富的、高质量的抗体,包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素(Ubiquitin)等识别抗体,应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。 另外,Rockland也生产特别齐全的二抗,包括纯化、生物素、HRP/ALP、荧光标记二抗,应用十分广泛。Rockland还对部分设施进行了GMP改造,以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图,提高其他产品的质量标准和管理水平。Rockland还不断与时俱进,探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利,Rockland加快和科研单位合作,从深度和广度两维加速开发新产品,正在从一个OEM老厂走到前台,缩短与直接客户的距离。