Rockland/Androgen Receptor Antibody/200-301-H54/100 µg
商品编号：
200-301-H54
品牌：
rockland-inc
市场价：
¥7780.00
美元价：
4668.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AndrogenReceptorAntibodyProperties Description Anti-AndrogenReceptor(MOUSE)MonoclonalAntibody-200-301-H54 Host Mouse TargetSpecies Human KnownCrossReactivity Human Clonality Monoclonal156C135.2IgG1kappa Application WesternBlot:1-4µg/mL Immunohistochemistry:UserOptimized PhysicalState Liquid ShippingCondition DryIce Format IgG1 Label Unconjugated Concentration 0.5mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.05%(w/v)SodiumAzide StABIlizer 0.05%BSA GeneName AR RelevantLinks UniProtKB-P10275 NCBI-NP_000035.2 GeneID-367 |
AndrogenReceptorAntibodyDescription
Background
Anti-AndrogenReceptorAntibodydetectshumanAndrogenreceptor.Theandrogenreceptor(AR)isan~110kDaandrogen-dependenttranscriptionfactorthatisamemberofthesteroid/nuclearreceptorgenesuperfamily.TheARsignalingpathwayplaysakeyroleindevelopmentandfunctionofmalereproductiveorgans,includingtheprostateandepididymis.ARalsoplaysaroleinnonreproductiveorgans,suchasmuscle,hairfollicles,andbrain.AbnormalitiesintheARsignalingpathwayhavebeenlinkedtoanumberofdiseases,includingprostatecancer,Kennedy"sdiseaseandmaleinfertility.ThePI3K/AktsignalingpathwayplaysanimportantroleinregulatingARactivitythroughphosphorylationofARatSer213/210andSer791/790.GrowthfactorsorcytokinesmayinducephosphorylationofARthroughthePI3K/Aktpathway.IGF-1activatesthephosphatidylinositol3-kinase(PI3K)/AKTpathwayinLNCapathighpassagenumberandincreasesphosphorylationofofARatSer213/210(seewesternblot)andSer791/790.ThewesternblotresultsalsoshowthatinhibitionofthePI3K/AktpathwaybyLY294002priortoincubationwithIGF-1suppressedARphosphorylationatSer213/210.ActivationofthePI3K/AKtpathwayisthoughttohaveasurvivalroleinprostatecancerbyprotectingcellsfromapoptosis.Anti-AndrogenReceptorAntibodyisidealforinvestigatorsinvolvedinneuroscience,cytokinesandgrowthfactors,andtranscriptionfactors.
Synonyms
DHTR,NR3C4
Immunogen
AndrogenReceptorAntibodywasproducedinmicebyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacidsnearthen-terminusoftheAndrogenReceptor.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AndrogenReceptorAntibodyissuitbaleforuseinIHC(p)andWB.Expectabandapproximately110kDaonspecificlysates.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.
Purity/Specifity
Anti-AndrogenReceptorAntibodywaspurifiedbyProteinGchromatography.ABLASTanalysiswasusedtosuggestcross-reactivitywithAnti-AndrogenReceptorfromhumanandNewWorldMonkeyon100%homologywiththeimmunizingsequence.Cross-reactivitywithAnti-AndrogenReceptorfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍
美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。 另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。
