Rockland/AGAP2 Antibody/200-401-946/100 µg
商品编号：
200-401-946
品牌：
rockland-inc
市场价：
¥7180.00
美元价：
4308.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AGAP2AntibodyProperties Description Anti-AGAP2(RABBIT)Antibody-200-401-946 Host Rabbit TargetSpecies Human KnownCrossReactivity human,mouse Clonality Polyclonal Application PhysicalState Lyophilized ShippingCondition Ambient Format IgG Label Unconjugated Concentration 2.0mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 ReconstitutionVolume 100µL ReconstitutionBuffer Restorewithdeionizedwater(orequivalent) Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName AGAP2 RelevantLinks NCBI-7661962 UniProtKB-Q99490 GeneID-116986 |
AGAP2AntibodyDescription
Background
Thisantibodyisdesigned,produced,andvalidatedaspartofacollaborationbetweenRocklandandtheNationalCancerInstitute(NCI).AGAP2(alsoknownasArf-GAPwithGTPase,ANKrepeatandPHdomain-containingprotein2)isaGTPaseactivatingproteinthatinactivatesArf.TheexpressionofAGAP2isamplifiedinhumanglioblastomacells.GTPase-activatingprotein(GAP)forARF1andARF5,whichalsoshowsstrongGTPaseactivity.Itmediatesanti-apoptoticeffectsofnervegrowthfactorbyactivatingnuclearphosphoinositide3-kinase.Isoform1participatesinthepreventionofneuronalapoptosisbyenhancingPI3kinaseactivity.Itaidsthecouplingofmetabotropicglutamatereceptor1(GRM1)tocytoplasmicPI3kinasebyinteractingwithHomerscaffoldingproteins,andseemstomediateanti-apoptoticeffectsofNGFbyactivatingnuclearPI3kinase.Isoform2doesnotstimulatePI3kinasebutmayprotectcellsfromapoptosisbystimulatingAkt.Italsoregulatestheadapterprotein1(AP-1)-dependenttraffickingofproteinsintheendosomalsystem.Itseemstobeoncogenic.Itisoverexpressedincancercells,preventsapoptosisandpromotescancercellinvasion.Anti-AGAP2AntibodyisusefulforresearchersinterestedinDevelopmentalBIOLOGy,apoptosis,Cancer,Immunology,andNuclearSignalingresearch.
Synonyms
rabbitanti-AGAP2antibody,AGAP-2,AGAP2,Arf-GAPwithGTPase,ANKrepeatandPHdomain-containingprotein2antibody,ArfGAPwithGTPasedomain,ankyrinrepeatandPHdomain2antibody,centauringamma1antibody,Centg1antibody
Immunogen
ThisproteinApurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitharecombinantproteincorrespondingtoaminoacids1-836ofhumanAGAP2protein.
ImmunogenType
RecombinantProtein
StorageCondition
Storevialat4°Cpriortorestoration. Forextendedstoragealiquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing. Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature. Thisproductisstableforseveralweeksat4°Casanundilutedliquid. Diluteonlypriortoimmediateuse.
ApplicationNote
ThisproteinApurifiedantibodyhasbeentestedforuseinELISAandwesternblot. Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandapproximately90kDainsizecorrespondingtoAGAP2proteinbywesternblottingintheappropriatecelllysateorextract.
Purity/Specifity
ThisproteinApurifiedantibodyisdirectedagainsthumanAGAP2protein.TheproductwaspurifiedfrommonospecificantiserumbyproteinAchromatography. ABLASTanalysiswasusedtosuggestcrossreactivitywithAGAP2proteinfrommouseandratbasedon93%and95%protein:proteinhomologies,respectively,withtheimmunizingsequence. Reactivityagainsthomologuesfromothersourcesisnotknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍
美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。 另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。
