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Rockland/Alpha Synuclein phospho S129 Antibody/612-401-C70/100 µL
Rockland/Alpha Synuclein phospho S129 Antibody/612-401-C70/100 µL
商品编号：
612-401-C70
品牌：
rockland-inc
市场价：
¥7100.00
美元价：
4260.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AlphaSynucleinphosphoS129AntibodyProperties Description Anti-alphaSynucleinpS129(Rabbit)Antibody-612-401-C70 Host Rabbit TargetSpecies Rat KnownCrossReactivity rat Clonality Polyclonal Application ELISA:1:10,000 WesternBlot:1:1000 PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.01MHEPES,0.15MSodiumChloride,pH7.5 StABIlizer 0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol GeneName SNCA RelevantLinks NCBI-NP_062042.1 UniProtKB-P37377 GeneID-29219 |
AlphaSynucleinphosphoS129AntibodyDescription
Background
AlphaSynucleinpS129AntibodydetectsAlpha-synucleinphosphorylatedatS129.Alpha-synucleinisapresynapticneuronalproteinthatisthoughttobeinvolvedintheformationofSNAREcomplexes.Mostsignificantly,aggregatedalpha-synucleinisoneofthemajorcomponentsfoundintheLewybodiesthatoccurinParkinson’sdisease(PD)andotherneurodegenerativedisorders.Mutationofthealpha-synucleingeneisassociatedwithfamilialformsofPD.Recentevidencesuggeststhatphosphorylationofalpha-synucleinatSer129playsaroleintheformationofinclusionsinPD.Anti-Alpha-synucleinantibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
Non-AbetacomponentofADamyloid,Non-A4componentofamyloidprecursor
Immunogen
Anti-AlphaSynucleinpS129AntibodywasproducedbyrepeatedimmunizationswithasyntheticphosphopeptidecorrespondingtoaminoacidresiduessurroundingSer129.
ImmunogenType
Peptide
PostTranslationalModification
Phosphorylation
StorageCondition
Storevialat-20°Cpriortoopening.Thisproductisstableat4°Casanundilutedliquid.Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow.Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
AlphaSynucleinpS129antibodyissuitableforuseinELISA,WesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately15kDainsizecorrespondingtothealphasynucleinproteinphosphorylatedatSer129intheappropriatecelllysateorextract.
Purity/Specifity
Anti-AlphaSynucleinpS129AntibodyisdirectedagainstratAlpha-synucleinphosphorylatedatS129.Theantibodywaspreparedfrommonospecificantiserumbyimmunoaffinitychromatographyusingphosphopeptidecoupledtoagarosebeadsfollowedbysolidphaseadsorption(s)againstnon-phosphopeptideandnon-specificpeptidetoremoveanyunwantedreactivities.Assaybyimmunoelectrophoresisresultedinasingleprecipitinarcagainstanti-RabbitSerum.ThisantibodyisspecificforphosphorylatedAlpha-synuclein.Minimalreactivityoccursagainstnon-phosphorylatedAlpha-synuclein.ReactivityagainstAlpha-synucleinoccursfromratsources.Reactivityisexpectedagainstthefollowingspeciesbasedon100%sequencehomology:bovine,canine,human,mouse,andnon-humanprimate.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
品牌介绍
美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。 另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。
