Rockland/AP2M1 Antibody/600-901-G75/100 µg

来自 : 发布时间：2025-01-15

AP2M1 Antibody Properties Description Anti-AP2M1 (Chicken) Antibody - 600-901-G75 Host Chicken Target Species Human Known Cross Reactivity Human, Mouse, Rat Clonality Polyclonal Application Western Blot : 1-2 ug/mL Physical State Liquid (sterile filtered) Shipping Condition Dry Ice Format IgG Label Unconjugated Concentration 1.0 mg/mL by UV absorbance at 280 nm Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 Preservative 0.01% (w/v) Sodium Azide GeneName AP2M1 Relevant Links NCBI - NP_004059UniProtKB - Q96CW1GeneID - 1173

AP2M1 Antibody Description

Background AP2M1 antibody detects human AP2M1. The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist. Anti-AP2M1 antibodies are ideal for investigators involved in infectious disease and enzyme research. Synonyms CLAPM1, KIAA0109 Immunogen AP2M1 Antibody was produced in chicken by repeated immunizations with a peptide near the c-terminus of human AP2M1. Immunogen Type Peptide Storage Condition Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. Application Note Anti-AP2M1 Antibody is suitable for use in E,WB, and IHC. Expect a band approximately ~49.6kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user. Purity/Specifity Anti-AP2M1 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with AP2M1 with Human, Rat and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with AP2M1 from other sources has not been determined. Disclaimer Note-General This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.